Many newly discovered, and possibly life-saving, drug compounds do not possess sufficient solubility or permeability in the digestive tract to make it to production status. Amorphous and nanocrystalline drug dispersions are being developed to overcome these issues but result in secondary issues with product stability. In a recent report, we have used the total scattering… Read More TSPDF correlates variation in local structure with kinetic behavior in amorphous pharmaceutical formulations
A team led by researchers from Brookhaven National Laboratory (BNL) and Cornell University recently conducted a series of experiments which intimate a strong parental connection between the so called “electron density wave” phase and the “pseudo gap” phase, key components seen as responsible for superconductivity in high temperature superconductors. Led by Séamus Davis, a physicist… Read More Unraveling the cuprates: scientists demonstrate link between key components in high temperature superconductivity
Last month we said goodbye to our favorite postdoc Kirsten Jensen. We are happy to report that she has accepted an Assistant Professorship in the Department of Chemistry at University of Copenhagen where she will be working on the synthesis and characterization of nanomaterials. During her time at Columbia, Kirsten focused on developing and using new thin-film… Read More Kirsten accepts faculty position at University of Copenhagen
Many modern material systems contain heterogeneous mixtures of components, and it is important to be able to characterize the structures of the components in such mixtures. Working with low concentrations is often desirable, either to achieve the proper pharmacokinetic properties of a drug molecule or to prevent particle aggregation and settling. To study structure in… Read More PDF Detects Nanoparticles in Dilute Solutions
Congratulations to Chenyang for successfully defending his thesis! In the first hour of his defense, which was open to the public, Chenyang delivered a riveting presentation on the structure and lattice dynamics of low-dimensional materials. During his time with the Billinge group, his research focused primarily on combined atomic pair distribution function and inelastic x-ray scattering techniques to… Read More Chenyang Completes Ph.D
Our recent work on tfPDF has been highlighted on the BNL website! Functional thin films are deposited onto a substrate, often silicon, silicon dioxide, or aluminum oxide. This makes it difficult to study the thin film structure because of the small amount of film material and large amount of substrate. To minimize the scattering of… Read More tfPDF: Thin film PDF
Combining X-ray diffraction and PDF with computed tomography allows for spatially resolved structural analysis, which can help unravel structures in heterogeneous materials and map out the phases present in the system. We recently demonstrated this in a paper on complex structures in batteries, where we were able to map out the components in commercial AAA batteries… Read More X-ray diffraction computed tomography reveals inner structure in batteries
A huge congratulations to Xiaohao for successfully defending his thesis! He has been an integral member of our group for the past four years and has carried out an exceptional graduate career pushing the boundaries in advanced algorithm development, complex modeling, and use of the pair distribution function technique for characterization of a wide range… Read More Xiaohao Successfully Defends!
A new cast of fantastic students joins the group this summer: undergraduate students, Justin Calamari and Erica Yee, and PhD student Tim Liu. From developing databases for cataloguing and predicting materials structure-property relationships, to modeling fundamental scattering behavior of X-rays, and complex modeling for structure solution of complex materials, We are excited to have them… Read More New Students Join the Group!
As part of an ongoing collaboration between Columbia University and the University of Glasgow, a select few graduate/post-doctoral fellows are chosen annually and provided funding for short visits to both schools. Max plans on conducting his exchange in the Fall, with a proposal to continue a study of degradation products found in the famous Mary… Read More Max Awarded Columbia-Glasgow Exchange Fellowship