TSPDF correlates variation in local structure with kinetic behavior in amorphous pharmaceutical formulations

Many newly discovered, and possibly life-saving, drug compounds do not possess sufficient solubility or permeability in the digestive tract to make it to production status. Amorphous and nanocrystalline drug dispersions are being developed to overcome these issues but result in secondary issues with product stability.

lactose_anomersIn a recent report, we have used the total scattering pair distribution function (TSPDF) technique to study the effects of processing on the product structure and kinetic behavior of different formulations of amorphous lactose. Lactose is a popular excipient (drug carrier) and tabletting agent for a wide variety of pharmaceutical products. We have demonstrated a wide variety of uses for TSPDF on pharmaceutical products such as product/formulation fingerprinting, phase quantification, and observing kinetic behavior. We are not only able to see the different structures that form during the recrystallization process, but also observe subtle structural differences in local molecular ordering that may underpin the very stability of the products.

We hope that this work will help lead to better tools for predicting product performance through a more fundamental understanding of product structure.

See here for the full report.